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GPAT 2020
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GPAT 2020 Pharmacy Solved Questions Paper
1. Relative sweetness of sucrose, to saccharin:
  • 1) 1: 400
  • 2) 1: 100
  • 3) 1: 500
  • 4) 1: 200
 Answer: 3)
 Explanation: 1: 500
2. Following statement is more accurate with respect to limitations of Arrhenius relationship for stability prediction:
  • 1) Less relative humidity and oxygen solubility at higher temperature
  • 2) Equal moisture concentrations will be mentioned at different temperatures
  • 3) Order of degradation will alter at higher temperature
  • 4) Same degradation mechanisms may predominate at different temperatures
 Answer: 1)
 Explanation: Less relative humidity and oxygen solubility at higher temperature
3. Lakes of Dyes available commercially contain maximum upto ………… of pure dye.
  • 1) 25%
  • 2) 10%
  • 3) 15%
  • 4) 50%
 Answer: 4)
 Explanation: 50%
4. Type II glass containers are
  • 1) Suitable for non-aqueous preparations
  • 2) Suitable for most acidic and neutral aqueous preparations
  • 3) Most inert glasses and shows high hydrolytic resistance
  • 4) Suitable for alkaline solutions
 Answer: 2)
 Explanation: Suitable for most acidic and neutral aqueous preparations
5. Dimethyl sulfoxide acts as penetration enhancer for topical formulations by
  • 1) Increasing transepidermal loss
  • 2) Denaturing proteins
  • 3) Increasing solubility
  • 4) Altering solvent nature of membrane
 Answer: 2)
 Explanation: Denaturing proteins
6. As per European Pharmacopoeia technical guide, substance stored at 25°C for 24 hours at 80% RH, called very hygroscopic when increase in weight is
  • 1) > 15% w/w
  • 2) > 0.2% w/w and < 20% w/w
  • 3) 0.2% w/w and <15% w/w
  • 4) 0.2% w/w and < 2% w/w
 Answer: 1)
 Explanation: > 15% w/w
7. SCHICK Test Toxin is a sterile Filtrate from a culture of
  • 1) Actinobacillus mallei
  • 2) Coryne bacterium Diphtheriae
  • 3) Mycobacterium Diphtheriae
  • 4) Rickettsia prowazeki
 Answer: 2)
 Explanation: Coryne bacterium Diphtheriae
8. Violin gut is obtained from intestine of
  • 1) Sheep
  • 2) Cat
  • 3) Horse
  • 4) Camel
 Answer: 1)
 Explanation: Sheep
9. An excipient Ludipress used for liquid Dosage form is a coprocessed excipient of
  • 1) Dextrose monohydrate + Kollidon 30 + Kollidon CL
  • 2) Lactose monohydrate + Kollidon 30 + Kollidon CL
  • 3) Lactose monohydrate + Kollidon 30
  • 4) PticInsi. Dextrose monohydrate + Kollidon 30
 Answer: 2)
 Explanation: Lactose monohydrate + Kollidon 30 + Kollidon CL
10. Pyrogens present in containers can be destroyed by heating the containers at
  • 1) 210°C for 4 h
  • 2) 121°C for 30 mins
  • 3) 121°C for 15 mins
  • 4) 210°C for 1 h
 Answer: 1)
 Explanation: 210°C for 4 h
11. In capsule making the Bloom strength of gelatin is proportional to molecular weight of the gelatin and is a measure of the
  • 1) Adhesive strength of gelatin with dipping pins
  • 2) Cohesive strength of the crosslinking that occurs between gelatin molecules
  • 3) Cohesive strength of the solvent molecules
  • 4) Adhesive strength of gelatin with other polymer
 Answer: 2)
 Explanation: Cohesive strength of the crosslinking that occurs between gelatin molecules
12. Choose the wrong statement from the following with regard to Amorphous solids
  • 1) Considered as super cooled fluids
  • 2) They tend to flow when subjected to sufficient pressure
  • 3) Usually they are anisotropic
  • 4) They do not have definite melting point
 Answer: 3)
 Explanation: Usually they are anisotropic
13. The 'Crenulation' effect on the cell wall is caused by_________ solutions and this effect is__________.
  • 1) Hypertonic; irreversible
  • 2) Hypotonic; irreversible
  • 3) Hypotonic; reversible
  • 4) Hypertonic; reversible
 Answer: 4)
 Explanation: Hypertonic; reversible
14. The unequal attractive forces acting on the molecules at the surface of liquid gas interface when compared with molecular forces in the bulk of the liquid is due to:
  • 1) Abscence of cohesive force of attraction
  • 2) Less adhesive force of attraction
  • 3) Abscence of adhesive force of attraction
  • 4) Less cohesive force of attraction
 Answer: 2)
 Explanation: Less adhesive force of attraction
15. Following is the important sterol in faeces formed from cholesterol by bacteria in lower intestine:
  • 1) 7-Dehydrocholesterol
  • 2) Coprostanol
  • 3) 7-Hydroxy cholesterol
  • 4) Lithocholic acid
 Answer: 2)
 Explanation: Coprostanol
16. According to distribution law, select the appropriate expression for the concentration of a solute when it exist as monomer in solvent A and dimer in solvent B
(Assume CA = concentration of solute in solvent A
CB = concentration of solute in solvent B
α= degree of dissociation)
  • 1)
  • 2)
  • 3)
  • 4)
 Answer: 1)
 Explanation:
17. The drug concentration between Minimum effective concentration (MEC) and maximum safe concentration (MSC) is called
  • 1) Therapeutic range
  • 2) Therapeutic ratio
  • 3) Therapeutic index
  • 4) Toxic range
 Answer: 1)
 Explanation: Therapeutic range
18. Production of Acetyl methyl carbinol can be detected by which of the following test
  • 1) Citrate utilization test
  • 2) Indole test
  • 3) Voges-proskaver test
  • 4) Methyl red test
 Answer: 3)
 Explanation: Voges-proskaver test
19. The temperature dependence and the theory of viscosity is expressed by the following
  • 1) Higuchi equation
  • 2) Arrhenius equation of chemical kinetics
  • 3) Stern-Volmer equation
  • 4) Gibb's equation
 Answer: 2)
 Explanation: Arrhenius equation of chemical kinetics
20. Which of the following is not a fundamental (primary) factor considered for selection of a location for the construction of pharmaceutical or chemical plant
  • 1) Labor supply
  • 2) Market for products
  • 3) Soil
  • 4) Raw materials
 Answer: 3)
 Explanation: Soil
21. The following gram positive bacteria species is positive for the coagulase test (a test for the ability of bacteria to cause blood plasma to clot)
  • 1) S. Saprophyticus
  • 2) S. aureus
  • 3) S. epidermidis
  • 4) S. lactis
 Answer: 2)
 Explanation: S. aureus
22. The version of GMP in India that describe requirement of factory premises for manufacture of cosmetics
  • 1) Schedule M-I
  • 2) Schedule-M-II
  • 3) Schedule-M-III
  • 4) schedule-M
 Answer: 2)
 Explanation: Schedule-M-II
23. This fungus is also known as opportunistic pathogen, often isolated from warm-blooded animals.
  • 1) Penicillinium chrysogenum
  • 2) Penicillinum notatum
  • 3) Aspergillus niger
  • 4) Candida albicans
 Answer: 4)
 Explanation: Candida albicans
24. Which of the following will result in very closest value to the Glomerular Filteration Rate (GFR) ?
  • 1) Measure of Blood Urea Nitrogen (BUN)
  • 2) Albumin Clearance
  • 3) Insulin Clearance
  • 4) Creatinine Clearance
 Answer: 4)
 Explanation: Creatinine Clearance
25. While studying solid state physicochemical properties, the packing property of drug include
  • 1) Refractive index
  • 2) Solubility
  • 3) Heat capacity
  • 4) Entropy
 Answer: 1)
 Explanation: Refractive index
26. The Acidic polymers of Ribitol/Glycerol phosphate present in Gram positive microorganism are known as
  • 1) Peptidoglycans
  • 2) Teichoic acids
  • 3) Polysaccharides
  • 4) Lysozymes
 Answer: 2)
 Explanation: Teichoic acids
27. Increasing the proportion of the disperse phase of an emulsion by more than 60% may lead to
  • 1) Phase inversion
  • 2) Frothing
  • 3) Cracking
  • 4) Creaming
 Answer: 1)
 Explanation: Phase inversion
28. The second law of thermodynamics states that 'whenever a spontaneous process takes place, it is accompanied by an increase in the total energy of the universe! The equation that satisfies the above law is :
  • 1) S_universe = S_surrounding - S_system
  • 2) S_universe = S_system - S_surrounding
  • 3) S_universe = S_system + S_surrounding
  • 4) S_system = S_universe + S_surrounding
 Answer: 2)
 Explanation: S_universe = S_system + S_surrounding
29. The complexation of Quinine with hexyl salicylate is an example of absorption by
  • 1) Ion pair transport
  • 2) Penocytosis
  • 3) Facilitated transport
  • 4) Convective transport
 Answer: 1)
 Explanation: Ion pair transport
30. The polymorphs exhibit the following different properties Except:
  • 1) Chemical structures
  • 2) Solubilities
  • 3) Melting points
  • 4) X-ray crystal and diffraction patterns
 Answer: 1)
 Explanation: Chemical structures
31. Method of Study Drug Distribution pattern is :
  • 1) UV-visible spectrophotometry
  • 2) Flourimetry
  • 3) Nuclear magnetic resonance
  • 4) Mass spectrophotometry
 Answer: 4)
 Explanation: Mass spectrophotometry
32. Product of the following reaction:
  • 1)
  • 2)
  • 3)
  • 4)
 Answer: 4)
33. Which of the following powder shows the greatest degree of dustibility
  • 1) Potato Starch
  • 2) Fine charcoal
  • 3) Lycopodium powder
  • 4) Talcum powder
 Answer: 3)
 Explanation: Lycopodium powder
34. The dispersion of course material by shearing in a narrow gap between a static cone and a rapidly rotating cone is caused by
  • 1) Peptisation
  • 2) Electrical Dispersion
  • 3) Colloid Milk
  • 4) Ultrasonic Irradiation
 Answer: 3)
 Explanation: Colloid Milk
35. When the concentration of an aqueous sodium chloride solution has the same colligative properties as the solution in question, the value so obtained is known as
  • 1) Molarity
  • 2) Isotonicity value
  • 3) Normality
  • 4) Molality
 Answer: 2)
 Explanation: Isotonicity value
36. When adhesive attractions between molecules of different species exceeds cohesive attraction between like molecules, the deviation according to Raoult's law is said to be
  • 1) Neutral
  • 2) Positive
  • 3) Partial
  • 4) Negative
 Answer: 1)
 Explanation: Negative
37. Centistoke is the CGS unit for the following property
  • 1) Fluidity
  • 2) Coefficient of viscosity
  • 3) Surface tension
  • 4) Kinematic viscosity
 Answer: 4)
 Explanation: Kinematic viscosity
38. Molar heat capacity of a system is defined as :
  • 1) The amount of heat required to raise temperature of one mole of the system by one Fahrenheit
  • 2) The amount of heat required to decrease temperature of one mole of the system by one Fahrenheit
  • 3) The amount of heat required to decrease temperature of one mole of the system by one Kelvin
  • 4) The amount of heat required to raise temperature of one mole of the system by one Kelvin
 Answer: 4)
 Explanation: The amount of heat required to raise temperature of one mole of the system by one Kelvin
39. When a solid forms a gel more readily when gently shaken or otherwise sheared than when allowed to form the gel while the material is kept at rest, the phenomenon is known as
  • 1) Negative rheopexy
  • 2) Rheopexy
  • 3) Thixotropy
  • 4) Anti thixotropy
 Answer: 2)
 Explanation: Rheopexy
40. In the process of Extraction, ethanol is used as a solvent for
  • 1) Alkaloids
  • 2) Waxes
  • 3) Sucrose
  • 4) GUMS
 Answer: 1)
 Explanation: Alkaloids
41. Human Serum Albumin has a molecular weight of
  • 1) 59,000
  • 2) 44,000
  • 3) 65,000
  • 4) 34,000
 Answer: 3)
 Explanation: 65,000
42. Riboflavin, chemically is
  • 1) 8,9-diethyl isoalloxazine
  • 2) 8,9-dimethyl isoalloxazine
  • 3) 6,7-diethyl isoalloxazine
  • 4) 6,7-dimethyl isoalloxazine
 Answer: 4)
 Explanation: 6,7-dimethyl isoalloxazine
43. Burow's solution is
  • 1) Ammonium acetate solution strong
  • 2) Calcium phosphate solution strong
  • 3) Aluminium acetate solution strong
  • 4) Calcium hydroxide solution strong
 Answer: 3)
 Explanation: Aluminium acetate solution strong
44. Drug products that contain the same therapeutic moiety but as different salts, esters or complexes are called as
  • 1) Therapeutic alternatives
  • 2) Pharmaceutical alternative
  • 3) Pharmaceutical equivalents
  • 4) Therapeutic equivalents
 Answer: 2)
 Explanation: Pharmaceutical alternative
45. When six suppositories containing 20 percent of morphine hydrochloride in Theobroma oil are to be prepared, which of the following statement is correct ? (Given : Displacement value of morphine hydrochloride is 1.5; weight of each suppository is 1 g )
  • 1) The displacement value of morphine hydrochloride is to be ignored
  • 2) The displacement values of both morphine hydrochloride and Theobroma oil are to be considered
  • 3) The displacement value of morphine hydrochloride is to be considered
  • 4) The displacement value of Theobroma oil is to be considered
 Answer: 1)
 Explanation: The displacement value of morphine hydrochloride is to be ignored
46. Following amino acid does not exhibit optical isomerism:
  • 1) Leucine
  • 2) Glycine
  • 3) Alanine
  • 4) Serine
 Answer: 2)
 Explanation: Glycine
47. Fraction of administered dose (which may be -n form of an ester of salt) of active drug is termed as
  • 1) Intrinsic factor
  • 2) Formulation factor
  • 3) Activity factor
  • 4) Salt factor
 Answer: 4)
 Explanation: Salt factor
48. If two monosaccharides differ in their structure around a single carbon atom, they are called as
  • 1) Trimers
  • 2) Trioses
  • 3) Dimers
  • 4) Epimers
 Answer: 4)
 Explanation: Epimers
49. Which of the following is the example of "Invert Sugar"
  • 1) Lactose
  • 2) Lactulose
  • 3) Sucralose
  • 4) Sucrose
 Answer: 4)
 Explanation: Sucrose
50. Which of the following groups stabilizes carbocation in electrophilic aromatic substitution
  • 1) —N(CH<sub>3</sub>)<sub>3</sub><sup>+</sup> , —NO<sub>2</sub>
  • 2) - NH<sub>2</sub>, - OH
  • 3) -CN, -SO<sub>3</sub>H
  • 4) -COOH, -CHO
 Answer: 2)
 Explanation: - NH2, - OH
51. The mechanism of antiepileptic effect of Lamotrigine is by :
  • 1) Inhibition of Na<sup>+</sup> channels
  • 2) Blockade of NMDA receptors
  • 3) Inhibition of glutamate release
  • 4) Inhibition of Ca<sup>++</sup> channels
 Answer: 1)
 Explanation: Inhibition of Na+ channels
52. Closeness of a measured value to the true or accepted value is known as
  • 1) Precision
  • 2) Deviation
  • 3) Accuracy
  • 4) Bias
 Answer: 3)
 Explanation: Accuracy
53. Which of the following is Anti aromatic
  • 1)
  • 2)
  • 3)
  • 4)
 Answer: 1)
54. Globar source in infra-red spectrophotometer is
  • 1) Tungsten filament
  • 2) Rhodium wire heated in ceramic
  • 3) Silicon carbide rod
  • 4) Nichrome wire
 Answer: 3)
 Explanation: Silicon carbide rod
55. Cotrimoxazole is combination of trimethoprim with sulfamethoxazole. Which of the following statement is correct about Cotrimoxazole ?
  • 1) Trimethoprim : sulfamethoxazole are administered in a dose ratio of 5 :1 to achieve optimal synergistic effect.
  • 2) Most effective ratio of trimethoprim: sulfamethoxazole in plasma is 20:1.
  • 3) Cotrimoxazole is contraindicated during pregnancy.
  • 4) Cotrimoxazole is ineffective in treating respiratory tract infections.
 Answer: 3)
 Explanation: Cotrimoxazole is contraindicated during pregnancy.

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